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Recent News and Articles on the Keywords: hiv drugs + hiv drug + hiv  Related to the article below (Last Update: 5/5/2008)

Boehringer Ingelheim wins European approval for HIV drug Aptivus
Forbes, NY -
Aptivus is a protease inhibitor, a class of HIV drugs that interfere with virus replication, the German drug maker said in a statement. ...
European Commission Grants Full Approval Of HIV Protease Inhibitor ... Medical News Today (press release)
all 3 news articles »

Javno.hr
Official says Russia 'not ready' for tough HIV steps
The Associated Press -
Health advocates say such therapy is vital to Russia because of the particular way HIV has spread through the country. Up to 80 percent of Russia's 1.6 ...
INTERVIEW-Russia must grab chance to beat AIDS epidemic-UN Reuters
all 70 news articles »
Anti-HIV NanoViricide Drug Candidate Demonstrates Significant ...
FOXBusiness -
The Company is developing drugs against a number of viral diseases including H5N1 bird flu, seasonal influenza, HIV, hepatitis C, rabies, dengue fever, ...

Vanguard
PEPFAR drug store fire: Idigbe allays fears over HIV treatment ...
Vanguard, Nigeria -
Soon after the incident, anxiety swept through the entire HIV & AIDS intervention community locally and internationally, moreso amongst the community of ...
Rapid HIV test
The Gazette (Montreal), Canada -
Anti-retroviral drugs given to an HIV-exposed infant after birth do succeed in preventing infection. But the problem is that a pregnant woman must be tested ...
Deadly consequences of ignorance
The Gazette (Montreal), Canada -
Discredited German-born vitamin salesman Matthias Rath, now of South Africa, supports the denialist view that anti-HIV drugs are making people sick. ...

Ars Technica
Overcoming a synthetic obstacle for testing HIV drugs
Ars Technica, MA -
Although a successful therapy, HAART leaves behind small, hidden reservoirs of HIV-1. Current drugs cannot target these latent virus populations, ...
UN anti-narcotics arm and OPEC partner to curb HIV among drug users
UN News Centre -
In a programme called Treatnet II, OFID will provide $3 million to scale up drug prevention and treatment for those vulnerable to the spread of HIV. ...
Health Matters: HIV Research
WCTV, FL -
Doctors hope a drug based on this approach could be useful as a complement to existing drugs already used to treat HIV. They also think it could help ...
Indian pharma may export to Philippines
Times of India, India - May 4, 2008
Domestic companies including Cipla, Natco Pharma and Strides Arcolab are already exporting anti-HIV drugs to Africa and other countries. ...
Source: Google News

High Prevalence of Genotypic and Phenotypic HIV-1 Drug-Resistant Strains Among Patients Receiving … -
C Adj?, R Cheingsong, TH Roels, C Maurice, G … - JAIDS Journal of Acquired Immune Deficiency Syndromes, 2001 - jaids.org
... UNAIDS started a Drug Access Initiative (DAI) aimed at improving availability of
antiretroviral (ARV) therapy and other AIDS drugs to HIV-infected persons. ...

Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance -
MA Wainberg, G Friedland - JAMA, 1998 - Am Med Assoc
... Effective treatment of HIV infection with antiviral drugs can lead to diminutions
in the amount of viral RNA and virus detectable in blood; studies of these ...

Antiretroviral-Drug Resistance among Patients Recently Infected with HIV -
SJ Little, S Holte, JP Routy, ES Daar, M Markowitz … - New England Journal of Medicine, 2002 - content.nejm.org
... Time trends in primary resistance to HIV drugs in the United Kingdom:
multicentre observational study. BMJ ... HIV Drug Resistance. NEJM ...

[PDF] Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial -
J Durant, P Clevenbergh, P Halfon, P Delgiudice, S … - Lancet, 1999 - bms.com.ve
... 1 , 2 There are currently ten drugs available to treat HIV-1-infected patients in
France, including four protease inhibitors, and an additional three drugs ...
-

[PDF] The relation between baseline HIV drug resistance and response to antiretroviral therapy: re- … -
V DeGruttola, L Dix, RD'Aquila, D Holder, A … - Antivir Ther, 2000 - intmedpress.com
... To assess the relation between resistance to antiretroviral drugs for treatment
of HIV-1 infection and virological response to therapy, results from 12 ...
-

… Consequences of Discontinuing Combination Antiretroviral-Drug Therapy in HIV-Infected Patients with … -
SG Deeks, T Wrin, T Liegler, R Hoh, M Hayden, JD … - New England Journal of Medicine, 2001 - content.nejm.org
... J. Virol. 78: 4628-4637 [Abstract] [Full Text]; Richman, DD (2004). Benefits and
limitations of testing for resistance to HIV drugs. ... HIV Drug Resistance. ...

Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection Recommendations of an International … -
MS Hirsch, F Brun-Vezinet, RT D'Aquila, SM Hammer, … - JAMA, 2000 - Am Med Assoc
... 13-member physician panel with expertise in basic science, clinical research, and
patient care involving HIV resistance to antiretroviral drugs was reconvened ...

… drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors … -
RB Kim, MF Fromm, C Wandel, B Leake, AJ Wood, DM … - Journal of Clinical Investigation, 1998 - pubmedcentral.nih.gov
... W, Donelli G, Ortona L. Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection:
analysis of lymphocyte surface expression and drug-unrelated function. ...

Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection -
DL Paterson, S Swindells, J Mohr, M Brester, EN … - Annals of Internal Medicine, 2000 - annals.highwire.org
... different antiretroviral drugs over a prolonged period of time and who may be infected
predominantly with HIV strains that are resistant to multiple drugs. ...

… patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
FJ Palella Jr, KM Delaney, AC Moorman, MO Loveless … - N Engl J Med, 1998 - aids-clinical-care.highwire.org
... Therapy with combinations of these drugs, which inhibit either the viral ... with
significantly decreased morbidity and mortality in persons with HIV-1 infection. ...

Source: Google Scholar

HIV drug resistance risk in mothers reduced by combination of common drugs

BIRMINGHAM, Ala. -- New research from the University of Alabama at Birmingham (UAB) shows that adding a single dose of two common anti-HIV drugs can prevent HIV-positive pregnant women from developing resistance to an entire class of drugs, potentially improving future treatment options.

Providing tenofovir and emtricitabine with nevirapine during labor greatly reduces the extent of resistance to non-nucleoside reverse transcriptate inhibitors (NNRTIs), such as nevirapine, which HIV-positive women take to lower the risk of mother-to-child transmission during childbirth.

Benjamin Chi, M.D., assistant professor of obstetrics and gynecology at UAB, and colleagues, reported their findings online in this week’s edition of The Lancet. Chi said the drug combination reduced resistance to NNRTIs by more than half at six weeks after delivery. This finding is important because between 20 and 69 percent of women given nevirapine develop resistance to the NNRTIs after taking a single dose. Although resistance becomes undetectable one to two years after ingestion, there are concerns that it could still compromise a woman’s future treatment options.

In this study, 399 participants were randomly assigned to receive or not receive single dose tenofovir and emtricitabine along with routine care. Routine care meant starting the anti-HIV drug zidovudine (or AZT) at 32 weeks gestation, and then ingesting a single dose of nevirapine at the start of labor. Participants were healthy and did not yet require treatment with potent antiretroviral therapy. The main goal of the study was to see if there was a difference in the presence of NNRTI resistance mutations six weeks after giving birth. The study was conducted in Lusaka, Zambia between 2005 and 2007.

Overall, 12 percent of women given the tenofovir and emtricitabine dose developed NNRTI resistance, compared to 25 percent among those who did not receive the additional drugs. Tenofovir and emtricitabine appeared to be safe, with no attributable side effects. Although these additional drugs did prevent NNRTI resistance, their use did not lead to substantial reductions in mother-to-child HIV transmission.

These results are encouraging for places like Zambia, which must rely on nevirapine for both HIV prevention and treatment. “The simplicity and effectiveness of this regimen is an important aspect of this intervention,” Chi said.

“HIV-infected pregnant women who take nevirapine in labor now have an easy way to reduce some of the negative consequences associated with the drug.”

 

 

 
 
 
 
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