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Recent News and Articles on the Keywords: obesity genetics + obesity + new  Related to the article below (Last Update: 5/5/2008)


TopNews
Obesity studies explain genetic risks; lead to potential treatments
AFP -
PARIS (AFP) ? New investigations into obesity may identify people with an inherited risk of weight gain, explain why crash diets often fail and address a ...
New DNA Variants Found That Can Help To Pile On The Pounds Science Daily (press release)
British team discovers obesity gene Times Online
Gene sequence puts half of UK population at greater risk of ... guardian.co.uk
Telegraph.co.uk - Times of India
all 74 news articles »

Enews 2.0
The reason fat people find it hard to lose weight is found
Telegraph.co.uk, United Kingdom - May 4, 2008
The fundamental new insight into the cause of obesity comes from an international team lead by Dr Kirsty Spalding, Prof Jonas Fris?n and Prof Peter Arner ...
Fat Cells Renewed Yearly in Process That May Lead to Treatment Bloomberg
all 53 news articles »

GlobalTV
Researchers find networks of obesity genes
GlobalTV, Canada -
The researchers developed a new method of analyzing DNA and used it to discover that obesity is not only complex -- something already known -- but complex ...

New York Times
Redefining Disease
New York Times, United States -
The other, Bardet-Biedl, is marked by vision loss, obesity, diabetes and extra fingers and toes. The techniques are being applied to diseases for which the ...
The designer dairy cow
Australian Life Scientist, Australia -
Food quality is increasingly important, as consumers become more concerned with quality-of-life issues, particularly the adverse health effects of obesity. ...
UPI NewsTrack Health and Science News
United Press International -
The study, funded by the British Heart Foundation, could lead to better ways of treating obesity, researchers said. Scientists from Imperial College London ...
Six of the world's top scientists win 2008 Gairdner Awards for ...
Laboratory Products News, Canada -
"The work of the 2008 awardees has significant implications for how we treat everything from cancer, heart disease and diabetes, to obesity, ...
Proven: Body Wrap Can Take Inches Off Your Waste
WCBS-TV New York, NY - 58 minutes ago
"When you create a condition where you perspire a lot, you will lose weight," said Carla Wolper of the Obesity Research Center at St. Luke's Hospital. ...
New research finds obesity result of genetics, not diet
680 News, Canada - Apr 13, 2008
She told 680News that 70 per cent of obesity is genetic. "I think the culture pretty much says that if you're obese it's your fault; just push away from the ...
Stanford in study on new weight-loss therapy
San Francisco Chronicle,  USA - Apr 15, 2008
A staggering range of explanations exist for obesity - such as metabolic conditions, genetics, and emotional and social factors - and it's highly unlikely ...
Source: Google News

Diseases of liporegulation: new perspective on obesity and related disorders -
RH UNGER, L ORCI - The FASEB Journal, 2001 - FASEB
... review in a rodent model of genetic obesity, the fa ... etiology for the complications
of human obesity, it would ... L. Diseases of lipid overflow: new perspective on ...

Obesity-Induced Hypertension New Concepts From the Emerging Biology of Obesity -
AL Mark, M Correia, DA Morgan, RA Shaffer, WG … - Hypertension, 1999 - Am Heart Assoc
... These findings from recent advances in the genetics and neuroendocrinology of obesity
introduce 2 new concepts regarding the regulation of blood pressure in ...

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis -
GA Bray, DA York - Physiological Reviews, 1979 - Am Physiological Soc
... rat (fa; fa?) B. Polygenic inbred 1. New Zealand obese ... are genetically at high risk
for obesity with animals that have no genetic predisposition for ...

[PDF] Obesity in the new millennium -
JM Friedman - Nature, 2000 - mcdb.colorado.edu
... basis of obesity, and possibilities for new treatments. ... and adoption studies all
indicate that obesity is largely the result of genetic factors (see ...
-

The nature of environmental influences on weight and obesity: A behavior genetic analysis -
CM Grilo, MF Pogue-Geile - Psychol Bull, 1991 - content.apa.org
... Behavior Genetics, 20, 33-43. ... In BB Wolman (Ed.), Psychological aspects of obesity:
A handbook (pp. 130-174). New York: Van Nostrand Reinhold. ...

Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model -
DB West, J Goudey-Lefevre, B York, GE Truett - J Clin Invest, 1994 - pubmedcentral.nih.gov
... Dietary obesity in nine inbred mouse strains. ... [PubMed] [Full Text]; Lander ES, Botstein
D. Mapping complex genetic traits in humans: new methods using a ...

The hormone resistin links obesity to diabetes -
CM Steppan, ST Bailey, S Bhat, EJ Brown, RR … - Nature, 2001 - nature.com
... New Eng. ... 3. Kopelman, PG Obesity as a medical problem. ... 4. Kahn, CR, Vicent, D. & Doria,
A. Genetics of non-insulin-dependent (type II) diabetes mellitus. Annu. ...

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation -
M Ristow, D Muller-Wieland, A Pfeiffer, W Krone, … - New England Journal of Medicine, 1998 - content.nejm.org
... Genetic Polymorphisms in Peroxisome Proliferator-Activated ... The investigation and
management of obesity. ... A New Selective Peroxisome Proliferator-Activated ...

… lipase: genetic mapping, identification of a new dinucleotide repeat, and association with obesity … -
J Magre, H Laurell, C Fizames, PJ Antoine, C Dib, … - Diabetes, 1998 - ncbi.nlm.nih.gov
1998 Feb;47(2):284-6. Human hormone-sensitive lipase: genetic mapping, identification
of a new dinucleotide repeat, and association with obesity and NIDDM. ...

… Basis of Plasma Variation in Adiponectin, a Global Endophenotype for Obesity and the Metabolic … -
AG Comuzzie, T Funahashi, G Sonnenberg, LJ Martin, … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc
... These QTLs could potentially reveal new genetic pathways with significant effects
on the biology of obesity, the metabolic syndrome, and their associated ...

Source: Google Scholar

New insight into the link between genetics and obesity

Scientists have acquired new insight into how the ‘obesity gene’ triggers weight gain in some individuals. Their findings, reported online today in Science Express, could have implications for the future treatment of obesity as well as adult onset diabetes.

Earlier this year a team of British geneticists discovered that variation in a gene called FTO influence people’s risk of becoming obese. While genetic defects causing human obesity had been previously described, the FTO discovery was of considerable interest because the genetic variant in FTO that predisposes to obesity is very common.

About half the UK population carry a copy of the variant and they are on average 1.6 kilograms heaver than those who don’t have the variant, while 16% of the population carry two copies of the variant and are on average three kilograms heavier. Carriers of the variant also had an increased risk of diabetes. However the function of FTO was completely unknown.

Researchers from the University of Cambridge, Oxford University and Cancer Research UK, London, have found that the FTO gene, codes for an enzyme that can act directly on DNA to modify it – suggesting that it might have a role in controlling the turning on and off of other genes.

They also found that FTO is highly expressed in a region of the brain, called the hypothalamus, which has important roles in the control of hunger and satiety and that, in certain parts of the hypothalamus, the levels of FTO are influenced by feeding and fasting.

This work benefited from an unusual and exciting collaboration. Initially, the Cambridge/London and the Oxford teams were working independently on this problem but recently pooled their complementary expertise to ensure that the findings were reliably repeatable using different approaches in different laboratories.

Professor Stephen O’Rahilly, who led the Cambridge part of the collaboration, said: “This is the first glimpse into the possible mechanisms whereby this very common genetic variant might influence a person’s risk of obesity. The finding that FTO is an enzyme with these actions on DNA is very surprising and a lot of work is still needed to work out how its actions influence body weight.

“The finding that FTO may have some involvement in the control of the function of the hypothalamus suggest that, like other obesity genes previously discovered, it may play some role in the influencing how well the brain senses hunger and fullness. As the activity of FTO can be altered by small molecules like metabolites, it is possible, in the future, that FTO could be manipulated therapeutically to help treat obesity.”

Sara Hiom, director of health information at Cancer Research UK, said: "This is an important piece of research. We know that obesity increases people's risk of developing a range of cancers as well as other diseases, and the increasing number of people who are overweight will have significant implications for cancer in the future. Unravelling how this gene works is very exciting and may one day lead to new treatments for obesity. However maintaining a healthy body weight through a balanced diet and regular physical activity is important for general health as well as reducing the risk of many cancers."
 
 
 
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